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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: J Immunol. 2020 Jun 26;205(3):830–841. doi: 10.4049/jimmunol.2000322

Figure 6. TRAF3 deficiency disrupts autoreactive B cell anergy.

Figure 6.

(A) Schematics of BM transfer experiments. (B) Representative flow data showing Ca2+ flux induced by HEL Ag in indicated B cells (group 1-4, n=5/group). (C) Relative level of secreted anti-HEL IgM induced by HEL/IL-4 in indicated B cell culture supernatant (n=5/group). ID of each group as labeled in (B). (D and E) Representative flow data showing surface IgM expression in the B cells of indicated donor and recipient mice. B cells were gated on B220+ populations. TRAF3-cKO, CD19Cre-Traf3f/f. Data are representative of 3 independently repeated experiments.