Figure 8.

PQQ improved [Ca²⁺]m homeostasis and reduced [Ca²⁺]m overload by maintaining NCLX levels. (A) The o-cresolphthalein complexone assay was used to determine the Ca²⁺ content in purified mitochondria isolated from rat myocardia. (B) Western blot analyses of MCU and NCLX in the sham, TAC, and TAC + PQQ groups. (C,D) Quantification of the MCU and NCLX protein levels in rat LV tissue. The data are expressed as the mean ± SD. **P<0.01 vs. sham. ^##P<0.01 vs. TAC. (E) Western blot analyses of MCU and NCLX in the control, Ang II, and Ang II + PQQ groups. (F, G) Quantification of the MCU and NCLX protein levels in NRVMs. The data are expressed as the mean ± SD. **P<0.01 vs. control. ^##P<0.01 vs. Ang II.