Table 4. Haplotypic association analysis of HMGB1 with AF in the Chinese Han population.
| Gene | Haplotype | N (%) | Pobs | Padj | OR (95% CI) | |
|---|---|---|---|---|---|---|
| Case (n=1,736) | Control (n=1,152) | |||||
| HMGB1 (rs1045411T/C-rs1412125C/T) | T-C | 62 (3.57) | 47 (4.08) | 0.583 | 0.377 | 1.31 (0.72–2.38) |
| T-T | 291 (16.76) | 176 (15.28) | 0.282 | 0.654 | 0.93 (0.66–1.29) | |
| C-C | 409 (23.56) | 266 (23.09) | 0.641 | 0.402 | 0.89 (0.66–1.18) | |
| C-T | 974 (56.11) | 663 (57.55) | – | – | – | |
Pobs, observed P value; Padj, P value adjusted for age, gender, hypertension, diabetes mellitus and smoking history; OR, odds ratio after the adjustment.