Table 5. Association analysis of the SNPs in HMGB1 with AF in the gender subgroups.
| SNP-allele | Model | Male (N=687) | Female (N=758) | |||||
|---|---|---|---|---|---|---|---|---|
| Pobs | Padj | OR (95% CI) | Pobs | Padj | OR (95% CI) | |||
| Rs1045411T | Allele | 0.944 | 0.300 | 1.25 (0.82–1.89) | 0.453 | 0.470 | 0.86 (0.57–1.30) | |
| ADD | 0.109 | 0.295 | 0.80 (0.52–1.22) | 0.652 | 0.464 | 1.17 (0.77–1.79) | ||
| DOM | 0.568 | 0.570 | 0.87 (0.53–1.42) | 0.382 | 0.235 | 1.34 (0.83–2.19) | ||
| REC | 0.065 | 0.104 | 0.36 (0.11–1.23) | 0.947 | 0.345 | 0.53 (0.14–1.97) | ||
| Rs1412125C | Allele | 0.494 | 0.660 | 1.09 (0.75–1.59) | 0.467 | 0.352 | 0.84 (0.59–1.21) | |
| ADD | 0.102 | 0.666 | 1.09 (0.75–1.57) | 0.784 | 0.358 | 0.85 (0.59–1.21) | ||
| DOM | 0.156 | 0.288 | 1.30 (0.80–2.09) | 0.565 | 0.554 | 0.87 (0.55–1.38) | ||
| REC | 0.275 | 0.356 | 0.65 (0.27–1.61) | 0.576 | 0.288 | 0.63 (0.27–1.47) | ||
SNP, single nucleotide polymorphism; Pobs, observed P value; Padj, P value after adjusting for age, hypertension, diabetes mellitus and smoking history; OR, odds ratio after the adjustment; ADD, additive model, rs145411_TT/CT/CC, rs1412125_CC/TC/TT; DOM, dominant model, rs145411_TT+CT/CC, rs1412125_CC+TC/TT; REC, recessive model, rs145411_TT/CT+CC, rs1412125_CC/TC+TT.