Table 6. Association analysis of the SNPs in HMGB1 with AF in the onset age subgroups.
| SNP-allele | Model | Early-onset | Late-onset | |||||
|---|---|---|---|---|---|---|---|---|
| Pobs | Padj | OR (95% CI) | Pobs | Padj | OR (95% CI) | |||
| Rs1045411T | Allele | 0.978 | 0.917 | 1.02 (0.76–1.36) | 0.324 | 0.618 | 1.17 (0.63–2.20) | |
| ADD | 0.357 | 0.912 | 0.98 (0.73–1.32) | 0.125 | 0.594 | 0.83 (0.42–1.64) | ||
| DOM | 0.648 | 0.592 | 1.10 (0.78–1.55) | 0.129 | 0.823 | 1.09 (0.51–2.32) | ||
| REC | 0.230 | 0.093# | 2.17 (0.88–5.56) | 0.347 | 0.009* | 11.1 (1.82–50.0) | ||
| Rs1412125C | Allele | 0.833 | 0.780 | 0.96 (0.74–1.25) | 0.885 | 0.430 | 0.80 (0.45–1.40) | |
| ADD | 0.095 | 0.789 | 0.97 (0.75–1.25) | 0.932 | 0.385 | 0.76 (0.41–1.42) | ||
| DOM | 0.152 | 0.128 | 0.63 (0.34–1.14) | 0.721 | 0.501 | 0.55 (0.10–3.11) | ||
| REC | 0.277 | 0.620 | 1.09 (0.78–1.52) | 0.999 | 0.471 | 0.76 (0.37–1.59) | ||
#, P<0.1; *, P<0.05. SNP, single nucleotide polymorphism; Pobs, observed P value; Padj, P value after adjusting for age, hypertension, diabetes mellitus and smoking history; OR, odds ratio after the adjustment; ADD, additive model, rs145411_TT/CT/CC, rs1412125_CC/TC/TT; DOM, dominant model, rs145411_TT+CT/CC, rs1412125_CC+TC/TT; REC, recessive model, rs145411_TT/CT+CC, rs1412125_CC/TC+TT.