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. 2020 Jul 7;13:6617–6628. doi: 10.2147/OTT.S249353

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© 2020 Zou et al.

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Xenograft tumor growth assay reveals the effect of BM-MSCs on the migration and invasion of HCT116-CSCs. (A) Mice are inoculated with BM-MSCs and HCT116-CSCs; (B) Nude mice xenograft tumors; (C) Volumes of nude mice xenograft tumors at various time points; (D) Weight of nude mice xenograft tumors at various time points; (E) Lungs of nude mice harboring xenograft tumors; (F) Intrapulmonary metastasis 6 weeks post-inoculation of BM-MSCs and HCT116-CSCs; (G) HE staining of xenograft tumors (× 400); (H) HE staining of lung specimens of nude mice harboring xenograft tumors (× 400). *Indicates metastatic foci from tumors (× 100). Ho indicates the amplification of the sites marked by * (× 400). **P < 0.01; ***P < 0.001.