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. 2020 Jul 10;15:4899–4918. doi: 10.2147/IJN.S244712

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© 2020 Tsolou et al.

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Empty (drug-free) PPSu-PEG NPs are not toxic to cells. HeLa K and MCF7 cells were treated with PPSu-PEG NPs for 48 h. (A) Bar graph demonstrating PPSu-PEG NPs’ toxicity (containing 0–500 μg/mL of polymer) on HeLa K and MCF7 cells, as obtained from WST-1 cell proliferation assay. Graph represents percentage (%) of viable cells ± SEM of 3 experiments. (B) Graphs represent normalized cell index of i) HeLa K cells and ii) MCF7 cells treated with PPSu-PEG NPs (containing 11 μg/mL of polymer) for 48 h. Graphs were obtained from the RTCA assay. NCI demonstrates a dip at 24h, corresponding to the NPs’ addition, after which CI increases again in all cases.