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. 2020 Jul 10;15:4899–4918. doi: 10.2147/IJN.S244712

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© 2020 Tsolou et al.

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Endocytosis pathways used for NPs cellular internalization in one cervical and three breast cancer cell lines. HeLa K, T47D, MCF7 and MDA-MB-231 cells were pretreated for 1 h with either 80 μM Dynasore or 50 μM EIPA followed by FA-PPSu-PEG-Rho NPs addition at a high concentration (11μg/mL polymer), and cells were monitored for 2 h. Graphs representing the real-time effect of Dynasore and EIPA on NPs internalization for 120 min post NPs addition are shown in (A) HeLa K (C) T47D (E) MCF7 and (G) MDA-MB-231 cells. Representative confocal images of NPs’ uptake in (B) HeLa K (D) T47D (F) MCF7 and (H) MDA-MB-231 cells at 120 min post treatment with NPs in the presence or absence of Dynasore or EIPA. Scale bar denotes 5μm.