Table 4.
Associations between serum transferrin receptor and anti-diphtheria, anti-pneumococcus serotype 19 and anti-polio serotype 2 serum IgG concentrations and/or seroconversion, in the birth cohort of Kenyan infants.
| DIPHTHERIA | |||
|---|---|---|---|
| Seronegative at 18 months: R2 = 0.322 | |||
| Odds ratio | 95% CI | ||
| Sex | 1.5 | 0.534, 3.969 | |
| Birthweight | 1.0 | 0.996, 1.000 (p = 0.0197) | |
| Anti-diphtheria IgG in cord blood | 1.0 | 0.283, 3.412 | |
| Anti-diphtheria IgG at age 10 wk | 0.002 | 0.000, 0.097 (p = 0.0016) | |
| Weight-for-age z-score (mean at 10 to 24 wk) | 1.4 | 0.798, 2.369 | |
| Serum transferrin receptor at 24 wk | 1.2 | 1.011, 1.315 (p = 0.0334) | |
| α-glycoprotein at 24 wk | 2.2 | 0.983, 5.127 | |
| Retinol binding protein at age 24 wk | 4.2 | 0.432, 39.888 | |
| PNEUMOCOCCUS SEROTYPE 19 | |||
| B | Standard error of B | Standardized β | |
| Anti-pneumococcus 19 IgG at 18 months: R2 = 0.130 | |||
| Sex | −0.127 | 0.120 | −0.110 |
| Birthweight | 0.578 | 1.022 | 0.063 |
| Anti-pneumococcus 19 in cord blood | −0.011 | 0.078 | −0.014 |
| Anti-pneumococcus 19 at age 10 wk | 0.242 | 0.094 | 0.273 (p = 0.0120) |
| Height-for-age z-score (mean at 10 to 24 wk) | −0.002 | 0.051 | −0.004 |
| Serum transferrin receptor at 24 wk | −0.908 | 0.423 | −0.247 (p = 0.0344) |
| α-glycoprotein at 24 wk | 0.195 | 0.214 | 0.093 |
| Retinol binding protein at age 24 wk | 0.744 | 0.456 | 0.170 |
| Odds ratio | 95% CI | ||
| Seronegative at 18 months: R2 = 0.146 | |||
| Sex | 1.9 | 0.754, 4.878 | |
| Birthweight | 1.0 | 0.999, 1.001 | |
| Anti-pneumococcus 19 in cord blood | 1.1 | 0.974, 1.296 | |
| Anti-pneumococcus 19 at age 10 wk | 0.6 | 0.279, 1.153 | |
| Height-for-age z-score (mean at 10 to 24 wk) | 0.9 | 0.633, 1.346 | |
| Serum transferrin receptor at 24 wk | 1.2 | 1.013, 1.342 (p = 0.0327) | |
| α-glycoprotein at 24 wk | 0.8 | 0.362, 1.737 | |
| Retinol binding protein at age 24 wk | 0.2 | 0.024. 1.781 | |
| POLIOMYELITIS SEROTYPE 2 | |||
| B | Standard error of B | Standardized β | |
| Anti-polio 2 IgG at 24 weeks: R2 = 0.103 | |||
| Sex | 0.046 | 0.091 | 0.056 |
| Birthweight | −0.037 | 0.838 | −0.006 |
| Anti-polio S2 in cord blood | −0.130 | 0.096 | −0.148 |
| Weight-for-age z-score (mean at 10 to 24 wk) | 0.030 | 0.044 | 0.092 |
| Serum transferrin receptor at 24 wk | −0.518 | 0.284 | −0.227 (p = 0.0719) |
| α-glycoprotein at 24 wk | −0.091 | 0.171 | −0.063 |
| Retinol binding protein at age 24 wk | 0.036 | 0.305 | 0.013 |
Analyzed using linear and logistic regression analyses.