Table 1.
Examples of LS nanoparticle-based vaccine candidates.
| Platform | Antigen | Target | Expression system | Reference |
|---|---|---|---|---|
| Icosahedral assemblies | ||||
| AaLS, T = 1 | OspA polypeptide |
Borrelia burgdorferi Borrelia bavariensis |
Escherichia coli | [72] |
| BaLS, T = 1 | PB10 peptide | Ricin Toxin | Escherichia coli | [16,32] |
| AaLS, T = 1 | OT-1 and OT-2* | antigen delivery to dendritic cells (DC) | Escherichia coli | [33] |
| Decameric Assemblies | ||||
| BspLS | Omp31** | Brucella abortus | Escherichia coli | [35,36] |
| Omp31 | Brucella ovis | |||
| BspLS-Omp31 chimera | Omp31 | Brucella ovis | via encoding DNA vaccine | [37] |
| BspLS | L7/L12 ribosomal protein | Brucella suis | Escherichia coli | [38] |
| BspLS | Stx2B Shiga toxin type 2 | enterohemorrhagic Escherichia coli (EHEC) | Escherichia coli | [39,40] |
| BspLS | OT 257-264 immunogenic T-cell epitope | cancer | Escherichia coli | [41] |
*
OT- Ovalbumin peptide.
**
Omp - Outer membrane protein.