Table 1.

Nomenclature of the culture variants originating from the Y strain clone H10.

Nomenclature	Significance	Drug pressure
H10–S	Parental clone from Y strain (S = ravuconazole sensitive), kept for short term in vitro (max. 8 culture passages after cloning)	N/A
H10-LT	H10–S clone after continuous in vitro culture (LT = long-term), in parallel with H10-R; control for genetic/phenotypic variation/aberration not due to drug pressure)	N/A
H10-R	H10–S clone maintained under increasing and on/off drug pressure, until reaching stable infection levels at 500 nM (R = ravuconazole resistant)	Yes (500 nM ravuconazole, constant pressure after phenotypic stabilization)
H10-R-NP	H10-R for which drug pressure was removed (NP = no pressure); investigation of resistance stability in the absence of drug pressure	No (vehicle only)