Table 2.

T. cruzi H10 clones and their susceptibility to ravuconazole.

Y strain clone		Exposure to ravuconazole – intracellular amastigotes – 96 h
Designation	Remarks	EC50 (nM)	aMA (%)
H10–S	Parental clone	5.4	86.9
H10-LT	Parental clone in long term culture	7.7	78.6
H10-R	Cultured in 500 nM ravuconazole	bND	36.4
H10-R-NP	H10-R off ravuconazole (“no pressure”)	2,920	71.5

^aMA, maximum activity; ^bND: values could not be calculated/determined.