. 2020 Apr 13;124(4):374–385. doi: 10.1017/S0007114520001312

Table 5.

Summary of findings from human studies investigating the effects of resistant starch (RS) on cell proliferation in the large bowel

(Medians and ranges)

Study	n (males/females)	Health status	Mean age (years)		Source of RS	RS dose (per d)	Intervention duration	Effect of RS on cell proliferation
Study	n (males/females)	Health status	Median	Range	Source of RS	RS dose (per d)	Intervention duration	Effect of RS on cell proliferation
van Munster et al. (1994)⁽⁵¹⁾	14 (9/5)	Healthy		28–73	High-amylose maize starch (Hylon VII, RS type 2)	45 g	2 weeks	Decreased
Humphreys et al. (2014)⁽³⁹⁾	23 (17/6)	Healthy		50–75	Butyrylated high-amylose maize starch (+ high-red meat diet)	40 g (+ 300 g red meat)	4 weeks	Restored (decreased) cell proliferation levels to baseline, when given second following high-red meat diet
Wacker et al. (2002)⁽²⁸⁾	12 (7/5)	Healthy	25		High-amylose maize starch (Hylon VII, RS type 2)	Males 59·7 g and females 50·7 g	4 weeks	No effect
Worthley et al. (2009)⁽²⁹⁾	17 (11/6)	Healthy	60		High-amylose maize starch (Hi-maize 958, RS type 2)	25 g	4 weeks	No effect
Present study	75 (40/35); 35 given RS	Healthy	52		High-amylose maize starch (Hi-maize 260, RS type 2)	23 g	7 weeks	Increased (in older participants)
Dronamraju et al. (2009)⁽³²⁾	62 (35/27)	Colorectal cancer	66		1:1 Blend of Novelose 240 (RS type 2) and Novelose 330 (RS type 3)	30 g	<4 weeks	Reduction in the proportion of mitotic cells in the top half of the crypt
Grubben et al. (2001)⁽²²⁾	23 (12/11); 13 given RS	Recently removed adenomas	57		High-amylose maize starch (Hylon VII, RS type 2)	45 g	4 weeks	No effect
van Gorkom et al. (2002)⁽²¹⁾	86 (53/30); 28 given RS	≥1 Sporadic adenoma(s) removed within 5 years	60		High-amylose maize starch (Hylon VII, RS type 2)	30 g	8 weeks	No effect
Burn et al. (2011)⁽⁵⁰⁾	131 (65/66); 61 given RS	Familial adenomatous polyposis	18		1:1 Blend of potato starch and high-amylose maize starch (Hi-maize 958, RS type 2)	30 g	1–12 years	No effect