Table 3. Genotype distributions in cases and controls for MTHFR C677T and A1298C polymorphisms in ovarian cancer.
| Author | Year | Country | Polymorphism | Case | Control | ||||
|---|---|---|---|---|---|---|---|---|---|
| AA∧ | Aa | aa | AA | Aa | aa | ||||
| Gao | 2012 | Asian | C677T | 97 | 100 | 27 | 232 | 178 | 22 |
| Jakubowska | 2012 | Caucasian | C677T | 423 | 446 | 116 | 1447 | 1481 | 422 |
| Ozkilic | 2016 | Middle Eastern | C677T | 18 | 28 | 4 | 19 | 30 | 5 |
| Pawlik | 2011 | Caucasian | C677T | 67 | 55 | 13 | 63 | 79 | 18 |
| Prasad | 2011 | Asian | C677T | 72 | 3 | 5 | 116 | 8 | 1 |
| Terry# | 2010 | Caucasian | C677T | 427 | 492 | 140 | 499 | 488 | 138 |
| Terry | 2010 | Caucasian | C677T | 71 | 72 | 10 | 210 | 217 | 55 |
| Terry | 2010 | Caucasian | C677T | 164 | 167 | 33 | 193 | 168 | 51 |
| Webb | 2011 | Caucasian | C677T | 744 | 709 | 185 | 571 | 568 | 139 |
| Wu | 2007 | Asian | C677T | 17 | 40 | 24 | 32 | 35 | 13 |
| Zhang | 2012 | Asian | C677T | 102 | 94 | 19 | 115 | 92 | 11 |
| Song | 2012 | Asian | A1298C | 107 | 77 | 16 | 112 | 79 | 9 |
| Terry | 2010 | Caucasian | A1298C | 515 | 430 | 93 | 534 | 450 | 109 |
| Terry | 2010 | Caucasian | A1298C | 68 | 67 | 18 | 236 | 200 | 48 |
| Terry | 2010 | Caucasian | A1298C | 173 | 149 | 42 | 189 | 180 | 43 |
| Webb | 2011 | Caucasian | A1298C | 770 | 693 | 175 | 598 | 561 | 119 |
∧
‘A’ represents wild-type allele and ‘a’ represents mutant allele.
#
Study separately genotyped subjects from three studies, the New England Case Control Study (NEC), Nurses’ Health Study (NHS), and Mayo Clinic Ovarian Cancer Case Control Study (MAY), thus were considered as three studies.