Table 4. Summary of different comparative results for MTHFR C677T polymorphisms in PCOS.
| Genotypes | Overall and subgroup | Participants | OR and 95%CI | Z value | P value | I2 (%) | Effect model# |
|---|---|---|---|---|---|---|---|
| TT vs. CT+ CC | Overall | 4,807 | 1.41 [1.20, 1.67] | 4.05 | 0.01 | 42 | F |
| Asian | 3,211 | 1.38 [0.99, 1.92] | 1.92 | 0.05 | 55 | R | |
| Caucasian | 994 | 1.09 [0.72, 1.65] | 0.39 | 0.7 | 0 | F | |
| Middle Eastern | 602 | 1.13 [0.39, 3.32] | 0.23 | 0.82 | 60 | R | |
| TT+ CT vs. CC | Overall | 4,807 | 1.54 [1.07, 2.22] | 2.31 | 0.02 | 85 | R |
| Asian | 3,211 | 1.76 [0.99, 3.13] | 1.62 | 0.05 | 90 | R | |
| Caucasian | 994 | 1.03 [0.78, 1.36] | 0.21 | 0.84 | 29 | F | |
| Middle Eastern | 602 | 2.66 [1.54, 4.58] | 3.52 | 0.01 | 53 | R | |
| CT vs. CC+ TT | Overall | 4,807 | 1.18 [1.04, 1.33] | 2.64 | 0.01 | 49 | F |
| Asian | 3,211 | 1.10 [0.95, 1.27] | 1.25 | 0.21 | 0 | F | |
| Caucasian | 994 | 0.99 [0.75, 1.31] | 0.05 | 0.96 | 40 | F | |
| Middle Eastern | 602 | 2.64 [1.27, 5.49] | 2.6 | 0.01 | 74 | R | |
| TT vs. CC | Overall | 2,872 | 1.47 [1.03, 2.11] | 2.1 | 0.04 | 59 | R |
| Asian | 1,929 | 1.58 [0.92, 2.72] | 1.67 | 0.09 | 75 | R | |
| Caucasian | 567 | 1.14 [0.72, 1.81] | 0.58 | 0.56 | 0 | F | |
| Middle Eastern | 376 | 2.21 [1.16, 4.21] | 2.41 | 0.02 | 0 | F | |
| T vs. C | Overall | 9,614 | 1.25 [1.06, 1.47] | 0.64 | 0.01 | 64 | R |
| Asian | 6,422 | 1.27 [1.01, 1.61] | 2.03 | 0.04 | 74 | R | |
| Caucasian | 1,988 | 1.04 [0.85, 1.27] | 0.34 | 0.73 | 19 | F | |
| Middle Eastern | 1,204 | 1.82 [1.39, 2.37] | 4.38 | 0.01 | 0 | F |
#
Effect model includes fixed-effect model (F) and random-effect model (R).