Table 5. Summary of different comparative results for MTHFR A1298C polymorphisms in PCOS.
| Genotypes | Overall and subgroup | Participants | OR and 95%CI | Z value | P value | I2 (%) | Effect model# |
|---|---|---|---|---|---|---|---|
| CC vs. AC+AA | Overall | 1,638 | 2.55 [1.61, 4.03] | 3.98 | 0.01 | 26 | F |
| Asian | 1,327 | 2.46 [1.44, 4.22] | 3.28 | 0.01 | 6 | F | |
| Caucasian | 173 | 1.37 [0.48, 3.90] | 0.59 | 0.55 | 0 | F | |
| CC+AC vs. AA | Overall | 1,638 | 1.84 [1.04, 3.28] | 2.09 | 0.04 | 81 | R |
| Asian | 1,327 | 1.33 [1.05, 1.67] | 2.4 | 0.02 | 14 | F | |
| Caucasian | 173 | 1.37 [0.74, 2.54] | 1.01 | 0.31 | 0 | F | |
| AC vs. AA+CC | Overall | 1,638 | 1.52 [0.89, 2.57] | 1.54 | 0.12 | 78 | R |
| Asian | 1,327 | 1.11 [0.88, 1.41] | 0.87 | 0.39 | 34 | F | |
| Caucasian | 173 | 1.25 [0.66, 2.39] | 0.69 | 0.49 | 0 | F | |
| CC vs. AA | Overall | 1,150 | 2.66 [1.68, 4.22] | 4.15 | 0.01 | 49 | F |
| Asian | 923 | 2.43 [1.41, 4.18] | 3.2 | 0.01 | 39 | F | |
| Caucasian | 115 | 1.51 [0.52, 4.42] | 0.75 | 0.45 | 0 | F | |
| C vs. A | Overall | 3,276 | 1.67 [1.03, 2.71] | 2.07 | 0.04 | 83 | R |
| Asian | 2,654 | 1.39 [1.14, 1.69] | 3.3 | 0.01 | 34 | F | |
| Caucasian | 346 | 1.31 [0.80, 2.14] | 1.08 | 0.28 | 0 | F |
#
Effect model includes fixed-effect model (F) and random-effect model (R).