Table 6. Summary of different comparative results for MTHFR C677T polymorphisms in ovarian cancer.
| Genotypes | Overall and subgroup | Participants | OR and 95%CI | Z value | P value | I2 (%) | Effect model# |
|---|---|---|---|---|---|---|---|
| TT vs. CT+ CC | Overall | 12,700 | 1.11 [0.88, 1.41] | 0.87 | 0.39 | 61 | R |
| Asian | 1,455 | 2.35 [1.59, 3.48] | 4.3 | 0.01 | 0 | F | |
| Caucasian | 11,141 | 1.82 [0.85, 3.93] | 0.72 | 0.47 | 16 | F | |
| TT+ CT vs. CC | Overall | 12,700 | 1.06 [0.99, 1.15] | 1.58 | 0.11 | 49 | F |
| Asian | 1,455 | 1.49 [1.19, 1.86] | 3.44 | 0.01 | 3 | F | |
| Caucasian | 11,141 | 1.02 [0.94, 1.10] | 0.46 | 0.64 | 32 | F | |
| CT vs. CC+ TT | Overall | 12,700 | 1.05 [0.97, 1.13] | 1.17 | 0.24 | 0 | F |
| Asian | 1,455 | 1.11 [0.88, 1.39] | 0.89 | 0.37 | 0 | F | |
| Caucasian | 11,141 | 1.04 [0.96, 1.13] | 0.92 | 0.36 | 22 | F | |
| TT vs. CC | Overall | 7,150 | 1.18 [0.89, 1.55] | 1.16 | 0.24 | 68 | R |
| Asian | 915 | 2.84 [1.88, 4.31] | 4.93 | 0.01 | 0 | F | |
| Caucasian | 6,199 | 0.97 [0.85, 1.11] | 0.41 | 0.68 | 25 | F | |
| T vs. C | Overall | 25,400 | 1.08 [0.96, 1.21] | 1.31 | 0.19 | 66 | R |
| Asian | 2,910 | 1.49 [1.26, 1.77] | 4.6 | 0.01 | 10 | F | |
| Caucasian | 22,282 | 1.00 [0.94, 1.06] | 0 | 1 | 29 | F |
#
Effect model includes fixed-effect model (F) and random-effect model (R).