Table 3. Subgroup analysis of the pooled HRs with SNHG15 expression in patients with cancer.

Subgroup analysis	No. of studies	No. of patients	Pooled HR(95%CI)	P	Heterogeneity		Model
					I2(%)	P-value
OS	12	1058	2.07 (1.48–2.88)	<0.0001	65	0.0008	Random
Type of analysis
Univariate analysis	8	462	2.20 (1.61–2.99)	<0.00001	0	0.94	Fixed
Multivariate analysis	4	596	1.93 (1.08–3.47)	<0.00001	77	0.004	Random
Tumor type
Digestive system cancer	4	520	2.57 (1.77–3.74)	<0.00001	0	0.9	Fixed
Respiratory system malignancy	4	163	2.16 (1.44–3.24)	<0.0002	0	0.71	Fixed
Female reproductive system malignancy	2	240	1.21 (0.88–1.65)	0.24	23	0.25	Fixed
Other system malignancy	2	115	2.05 (0.89–4.71)	0.09	0	0.59	Fixed
HR estimation method
Indirectly	5	257	1.86 (1.24–2.81)	0.003	0	0.98	Fixed
Directly	7	781	2.24 (1.39–3.59)	0.009	77	0.002	Random
number of patients
More than 60	6	791	2.04 (1.26–3.31)	0.004	74	0.002	Random
Less than 60	6	267	2.13 (1.48–3.06)	<0.00001	0	0.89	Fixed
Cut-off
Median-value	5	325	1.94 (1.32–2.84)	0.0007	0	0.96	Fixed
Mean-value	5	455	2.12 (1.13–3.97)	0.02	70	0.009	Random
NA	2	258	2.43 (1.57–3.77)	<0.0001	0	0.59	Fixed
Quality scores
Score = 9	9	779	1.79 (1.27–2.52)	0.0008	50	0.05	Random
Score < 9	3	279	2.58 (1.74–3.83)	<0.0001	0	0.72	Fixed
DFS	2	155	2.32 (1.53–3.53)	<0.0001	0	0.86	Fixed
PFS	1	182	1.12 (1.06–1.19)	0.0002	-	-	-

Abbreviations: DFS, disease-free survival; OS, overall survival; PFS, progression-free survival. Random, random-effect model; Fixed, fixed-effects model; directly, HR was extracted directly from the primary articles; indirectly, HR was extracted indirectly from the primary articles.