Table 4. Pool effects of Clinicopathologic characteristics in cancer patients with abnormal SNHG15 expression.
| Clinicopathological characteristics | No. of studies | No. of patients | Odds ratio (95% CI) | Heterogeneity | ||
|---|---|---|---|---|---|---|
| Fixed | Random | I2(%) | P-value | |||
| Age (old vs. young) | 13 | 1271 | 0.98 (0.78–1.22) | 0.98 (0.78–1.23) | 0.0 | 0.680 |
| gender (female vs. male) | 11 | 1031 | 1.07 (0.83–1.37) | 1.05 (0.78–1.41) | 23 | 0.220 |
| TNM (III+IV vs. I+II) | 13 | 1271 | 1.98 (1.57–2.51) | 2.52 (1.33–4.76) | 83.9 | 0.000 |
| Digestive system | 5 | 568 | 2.97 (2.09–4.23) | 2.96 (2.08–4.23) | 0 | 0.61 |
| Respiratory system | 3 | 139 | 3.04 (1.52–6.09) | 2.95 (1.13–7.73) | 45 | 0.16 |
| Female reproductive system | 1 | 182 | 2.14 (0.99–4.61) | 2.14 (0.99–4.61) | - | - |
| Other system malignancy | 4 | 382 | 0.96 (0.64–1.45) | 1.91 (0.21–17.20) | 94 | 0.000 |
| LNM (present vs. absent) | 11 | 937 | 2.09 (1.65–2.64) | 2.41 (0.99–5.87) | 87 | 0.000 |
| Digestive system | 4 | 416 | 3.00 (2.00–4.51) | 2.98 (1.98–4.49) | 0 | 0.450 |
| Respiratory system | 3 | 139 | 3.40 (1.67–6.91) | 3.39 (1.66–6.93) | 0 | 0.67 |
| Other system malignancy | 4 | 382 | 0.71 (0.46-1.09) | 1.39 (0.09–20.34) | 95 | 0.000 |
| Tumor size (big vs. small) | 8 | 761 | 1.48 (1.11–1.97) | 2.06 (1.03–4.13) | 79.0 | 0.000 |
| Digestive system | 3 | 371 | 1.24 (0.82–1.88) | 1.47 (0.56–3.88) | 77.0 | 0.010 |
| Respiratory system | 2 | 104 | 4.63 (2.02–10.66) | 4.63 (2.01–10.66) | 0 | 0.81 |
| Other system malignancy | 3 | 286 | 1.26 (0.79–2.02) | 1.88 (0.41–8.59) | 87.0 | 0.000 |
| Histological grade | 7 | 701 | 2.62 (1.90–3.59) | 2.59 (1.84–3.64) | 9.0 | 0.360 |
| Digestive system | 5 | 570 | 2.63 (1.84–3.76) | 2.64 (1.84–3.77) | 0.0 | 0.550 |
| Non-digestive system | 2 | 131 | 2.56 (1.27–5.15) | 2.05 (0.47–-9.04) | 72.0 | 0.060 |
| DM (present vs. absent) | 5 | 521 | 1.66 (1.02–2.72) | 1.64 (0.40–6.74) | 73.0 | 0.005 |
| Digestive system | 2 | 197 | 5.05 (2.15–11.85) | 5.10 (2.17–11.96) | 0.0 | 0.430 |
| Non-digestive system | 3 | 324 | 0.83 (0.43–1.61) | 0.66 (0.03–12.65) | 80.0 | 0.007 |
| Invasion depth (T3+T4/T1+T2) | 3 | 349 | 4.13 (2.55–6.67) | 3.60 (0.95–13.66) | 84 | 0.002 |
| smoking (smoker vs. non-smoker) | 2 | 84 | 1.03 (0.24–2.54) | 1.15 (0.26–5.11) | 59.0 | 0.120 |
Abbreviations: DM, distant metastasis; LNM, lymph node metastasis. Random, random-effect model; TNM, TNM stage; Fixed, fixed-effect model.