Table 1.
PD-L1 Expression (via Immunohistochemistry) and Clinical Characteristics of 118 Patients with Cervical Squamous Cell Carcinoma
| Clinical or Pathologic Features | Total No. | PD-L1 Expression in Tumor Cells | PD-L1 Expression in Stroma | ||||
|---|---|---|---|---|---|---|---|
| Positive | Negative | p value | Positive | Negative | p value | ||
| All cases | 118a | 69(58.5) | 49(41.5) | - | 51(43.2) | 67(56.8) | - |
| Age at diagnosis | 0.61 | 0.068 | |||||
| < 35 years old | 20 | 11(55.0) | 9(45.0) | 9(45.0) | 11(55.0) | ||
| 35–55 years old | 78 | 48(61.5) | 30(38.5) | 38(48.7) | 40(51.3) | ||
| >55 years old | 20 | 10(50.0) | 10(50.0) | 4(20.0) | 16(80.0) | ||
| Ethnicity | 0.37 | 0.80 | |||||
| Uygur | 63 | 35(55.6) | 28(44.4) | 27(42.9) | 36(57.1) | ||
| Han | 48 | 28(58.3) | 20(41.7) | 20(41.7) | 28(58.3) | ||
| Other minorities | 7 | 6(85.7) | 1(14.3) | 4(57.1) | 3(42.9) | ||
| Childbearing history | 0.008 | 0.067 | |||||
| 0–2 times | 60 | 28(46.7) | 32(53.3) | 21(35.0) | 39(65.0) | ||
| ≥ 3 times | 58 | 41(70.7) | 17(29.3) | 30(51.7) | 28(41.3) | ||
| Abortion history | 0.001 | 0.66 | |||||
| Yes | 69 | 49(71.0) | 20(29.0) | 31(44.9) | 38(55.1) | ||
| No | 49 | 20(40.8) | 29(59.2) | 20(40.8) | 29(59.2) | ||
| HPV status | 0.17 | 0.22 | |||||
| HPV 16 | 44 | 24(54.5) | 20(45.4) | 20(45.5) | 24(54.5) | ||
| HVP18 | 35 | 22(62.9) | 13(37.1) | 18(51.4) | 17(48.6) | ||
| Other | 24 | 11(45.8) | 13(54.2) | 10(41.7) | 14(58.3) | ||
| Negative | 15 | 12(80.0) | 3(20.0) | 3(20.0) | 12(80.0) | ||
| Tumor size | 0.57 | 0.31 | |||||
| ≤ 4 cm | 47 | 26(55.3) | 21(44.7) | 23(48.9) | 24(51.1) | ||
| > 4 cm | 71 | 43(60.6) | 28(39.4) | 28(39.4) | 43(60.6) | ||
| Differentiation | 0.20 | 0.87 | |||||
| Low | 66 | 42(63.6) | 24(36.4) | 31(47.0) | 35(53.0) | ||
| Middle/High | 52 | 27(51.9) | 25(48.1) | 30(57.7) | 32(61.5) | ||
| FIGO stage | 0.95 | 0.14 | |||||
| IA ~ IIA2 | 51 | 30(58.8) | 21(41.2) | 26(51.0) | 25(49.0) | ||
| ≥ IIB | 67 | 39(58.2) | 28(41.8) | 25(37.3) | 42(62.7) | ||
| Lymph node metastases | 0.056 | 0.085 | |||||
| Yes | 30 | 22(73.3) | 8(26.7) | 17(56.7) | 13(43.3) | ||
| No | 88 | 47(53.4) | 41(46.6) | 34(38.6) | 54(61.4) | ||
Notes: Data were shown as number of cases (%). aTwo samples could not be evaluated for PD-L1 owing to sample conditions.