Figure 1.

Study Flow Chart

^aScreening and randomization visits can be combined provided that ¹⁵O-water PET and CFVR assessments are carried out on separate days.

^bThe 14-day time-window before surgery on day 0 can be reduced if the pre-operative conference, randomization, and delivery of AZD8601/placebo can be accommodated within a shorter period.

^cIncludes CFVR in the left anterior descending artery (for sites able to assess CFVR).

^dKansas City Cardiomyopathy Questionnaire, Seattle Angina Questionnaire, and NYHA classification.

^eIncludes high-sensitivity troponin T and NT-proBNP.

^fOptional digital assessments via mobile phone app.

X, assessment times; XXXXX, daily assessments during stay in hospital; 6MWT, 6-min walking test; CFVR, coronary flow velocity reserve; CT, computed tomography; MCWS, maximum continuously walked steps; NT-proBNP, N-terminal pro-B-type natriuretic peptide; NYHA, New York Heart Association; PET, positron emission tomography; TC, teleconference; VEGF-A, vascular endothelial growth factor.