Table 1. Properties of the Hub Nodes of the Main Connected Component .

Gene	Description	D	BC	CC	S
Ccl2	Immediate-early serum-responsive protein JE; Chemotactic factor that attracts monocytes, but not neutrophils; it belongs to the intercrine beta (chemokine CC) family.	41	0.007	0.69	610
Icam1	Intercellular adhesion molecule 1; During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups; it belongs to the immunoglobulin superfamily.	41	0.010	0.69	738
Cxcl10	10 kDa interferon gamma-induced protein; In addition to its role as a pro-inflammatory cytokine, it may participate in T-cell effector function and perhaps T-cell development.	39	0.026	0.67	938
Timp1	Tissue inhibitor of metalloproteinases 1; It functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. It plays a role in integrin signaling. Also, it stimulates steroidogenesis by Leydig and ovarian granuloma cells.	37	0.017	0.66	936
Fos	FBJ osteosarcoma oncogene; It regulates TGF-beta- mediated signaling. It has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation, and differentiation.	34	0.054	0.64	1892

Abbreviations: D, degree; BC, betweenness centrality; CC, closeness centrality; S, stress.

Descriptions are obtained from STRING database and are summarized.