Table 2. Biochemical Pathways Related to the 53 queried DEGs Included in the Main Connected Component of the PPI Network .
| R | GO Term | % AG | NG | AGF |
| 1 | Cytokine-cytokine receptor interaction | 4.43 | 12 | [Ccl12, Ccl2, Ccl3, Ccl4, Clcf1, Csf1, Cxcl10, Il17rb, Il6st, Lif, Tnfrsf1a, Tnfrsf9] |
| 2 | NF-kappa B signaling pathway | 5.77 | 6 | [Birc3, Ccl4, Icam1, Myd88, Nfkb2, Tnfrsf1a] |
| 3 | Osteoclast differentiation | 4.69 | 6 | [Csf1, Fos, Fosl1, Junb, Nfkb2, Tnfrsf1a] |
| 4 | Complement and coagulation cascades | 3.45 | 3 | [Plat, Pros1, Serpine1] |
| 5 | IL-17 signaling pathway | 7.69 | 7 | [Ccl12, Ccl2, Cxcl10, Fos, Fosl1, Il17rb, Lcn2] |
| 6 | MAPK signaling pathway | 3.07 | 9 | [Csf1, Epha2, Fos, Gadd45g, Map3k6, Myc, Myd88, Nfkb2, Tnfrsf1a] |
| Prolactin signaling pathway | 4.17 | 3 | [Esr2, Fos, Irf1] | |
| Colorectal cancer | 4.05 | 3 | [Fos, Gadd45g, Myc] | |
| Small cell lung cancer | 3.26 | 3 | [Birc3, Gadd45g, Myc] | |
| Breast cancer | 3.31 | 5 | [Esr2, Fos, Gadd45g, Myc, Nfkb2] | |
| 7 | TNF signaling pathway | 10.19 | 11 | [Birc3, Ccl12, Ccl2, Csf1, Cxcl10, Fos, Icam1, Junb, Lif, Sele, Tnfrsf1a] |
| AGE-RAGE signaling pathway in diabetic complications | 5.00 | 5 | [Ccl12, Ccl2, Icam1, Sele, Serpine1] | |
| Chagas disease (American trypanosomiasis) | 6.93 | 7 | [Ccl12, Ccl2, Ccl3, Fos, Myd88, Serpine1, Tnfrsf1a] | |
| African trypanosomiasis | 8.33 | 3 | [Icam1, Myd88, Sele] | |
| Malaria | 12.24 | 6 | [Ccl12, Ccl2, Icam1, Myd88, Sele, Selp] | |
| Influenza A | 3.57 | 6 | [Ccl12, Ccl2, Cxcl10, Icam1, Myd88, Tnfrsf1a] | |
| Rheumatoid arthritis | 7.23 | 6 | [Ccl12, Ccl2, Ccl3, Csf1, Fos, Icam1] | |
| Fluid shear stress and atherosclerosis | 5.63 | 8 | [Ccl12, Ccl2, Fos, Hmox1, Icam1, Plat, Sele, Tnfrsf1a] | |
| 8 | Toll-like receptor signaling pathway | 5.05 | 5 | [Ccl3, Ccl4, Cxcl10, Fos, Myd88] |
| Prolactin signaling pathway | 4.17 | 3 | [Esr2, Fos, Irf1] | |
| Salmonella infection | 5.13 | 4 | [Ccl3, Ccl4, Fos, Myd88] | |
| Pertussis | 4.00 | 3 | [Fos, Irf1, Myd88] | |
| Chagas disease (American trypanosomiasis) | 6.93 | 7 | [Ccl12, Ccl2, Ccl3, Fos, Myd88, Serpine1, Tnfrsf1a] | |
| Influenza A | 3.57 | 6 | [Ccl12, Ccl2, Cxcl10, Icam1, Myd88, Tnfrsf1a] | |
| Breast cancer | 3.31 | 5 | [Esr2, Fos, Gadd45g, Myc, Nfkb2] | |
| Rheumatoid arthritis | 7.23 | 6 | [Ccl12, Ccl2, Ccl3, Csf1, Fos, Icam1] |
The pathways are obtained from KEGG and group P-Value corrected with Bonferroni step down ≤0.01 was considered.