Figure 7.

A: Forest plot of hazard ratios (estimates and 95% CIs) from a multivariate Cox proportional hazards model of overall survival. Concordance Index: 0.73 # Events: 131; Global P value (log-rank): 3.4809 × 10⁻¹¹. Tumor-infiltrating lymphocyte (TIL) infiltration is a continuous variable calculated as the fraction of area predicted to contain tumor that is also predicted to contain lymphocytes (range, 0% to 63%), and then rescaled in terms of SDs (9.4%). The dotted line indicates a hazard ratio of 1. B: Kaplan-Meier plot of survival probability after dividing patients into high and low TIL infiltration groups around the mean TIL infiltration fraction for all cases (6.4%). C: Kaplan-Meier plot subdivided by PAM50 tumor subtype shows that TIL infiltration is prognostic within at least two groups defined by gene expression, Her2 and Luminal B (LumB). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 versus low. LumA, Luminal A; ref, reference.