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. 2020 Jul 11;2020:2153571. doi: 10.1155/2020/2153571

Figure 7.

Figure 7

Effects of paeoniflorin on the HPA axis of rats subjected to FST. (a) Plasma CRH, ACTH, and CORT significantly increased in M group, while F and P can reverse these changes. (b) Hippocampus CRH, ACTH, and CORT increased markedly in the M group, while F and P can reverse these changes. Compared with the NC group, ∗∗p < 0.01. Compared with the M group, ##p < 0.01; NC, normal control; M, model; F, fluoxetine; P, paeoniflorin; HPA, hypothalamic-pituitary-adrenal; FST, forced swimming test; CRH, corticotropin-releasing hormone; ACTH, adrenocorticotropic hormone; CORT, corticosterone.