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Effects of paeoniflorin on plasma BDNF and hippocampus NO of rats subjected to FST. (a) Plasma BDNF was significantly downregulated in the M group, while F and P can reverse this change. (b) Hippocampus NO obviously increased in the M group, while F and P can reverse this change. Compared with the NC group, ∗∗p < 0.01. Compared with the M group, ##p < 0.01. BDNF, brain-derived neurotrophic factor; NO, nitric oxide; FST, forced swimming test; M, model; F, fluoxetine; P, paeoniflorin.
