Table 1.
Zebrafish Regeneration Studies on Macrophage and Microglial Involvement.
| Tissue | Life Stage | Cell Type | References |
|---|---|---|---|
| Heart | Adult | Macrophage | [91,92,93,94,95,96,97,98,99] |
| Fin | Larvae | Macrophage | [89,97,100,101], |
| Fin | Adult | Macrophage | [87,97,102,103] |
| Hair Cell | Larvae | Macrophage | [104,105,106,107,108] |
| Retina | Adult | Microglia | [109,110,111,112] |
| Spinal Cord | Larvae | Microglia | [90,113,114,115] |
| Spinal Cord | Adult | Microglia | [116,117,118,119] |
| Brain (telencephalon, olfactory bulb) | Adult | Microglia | [72,85,120,121,122,123,124,125] |
Study of macrophages and microglia in relation to regeneration after injury is popular in both larvae and adult zebrafish models. There is noted difficulty in distinguishing microglia from infiltrating macrophages in many zebrafish studies, as semantic variability is prevalent throughout the literature.