Figure 8.

Mouse embryonic development (single-cell). Complete erasure of the zygote-CP (K = 30: n = 571 RNAs) occurs after the late 2-cell state (B) through the switching singular transition at the CP (K = 40: n = 428 RNAs). (C) A cell fate-guiding genome avalanche occurs from the middle 2-cell (2-cell M) to 4-cell states through the late 2-cell state (2-cell L), where the whole-genome PDF shifts from up- to downregulation and the scaling behavior (ln(nrmsf)< -11) reflects along the zero-fold change (y =0) to exhibit a coherent switching of folding and unfolding chromatin dynamics (see yellow solid and dashed arrows, respectively). The PDF shows that the CP is ON at the middle 2-cell – late 2-cell state, and OFF at the late 2-cell – 4-cell state and at the 4-cell state – 8-cell state. (D) Erasure of initial sandpile criticality occurs after the late 2-cell state, coinciding with the result of (A) and confirming the timing of the cell-fate change (after the late 2-cell state). Note: A traveling wave is also observed as seen in the human embryo cell (Figure 7C) between the zygote and other states.