Table 3.

Single cell: state change in the CP associated with coherent perturbation of the genome engine. Table provides summary of when and how the state change in the CP with perturbation of the genome engine occurs for mouse and human embryo development, and Th17 cell differentiation (from top to bottom row, respectively). * Cell fate-guiding state change occurs in the CP. ** Reprogramming in mouse and human embryo development.

Biological Regulation	Location of the CP	State Change * in the CP	Coherent Perturbation of Genome Engine	Reprogramming **/Cell-Fate Cange
Mouse Embryo Development	ln<nrmsf>CP ~ −5.6	ON → OFF: At late 2-cell - 4-cell	Suppression- Enhancement	After late 2-cell **
Human Embryo Development	ln<nrmsf>CP ~ −5.9	Singular Switching: At 8-cell -Morula	Suppression- Enhancement	After 8-cell **
Th17 Cell Immune Differentiation	ln<nrmsf>CP ~ −4.4	OFF → ON: At 6–9 h	Suppression- Enhancement	After 6 h