SSc	systemic sclerosis
dcSSc	diffuse cutaneous systemic sclerosis
lcSSc	limited cutaneous systemic sclerosis
ECM	extracellular matrix
αSMA	alpha-smooth muscle actin
MCP	matricellular protein
CCN	centralized coordination network
THBS	thrombospondin
SPARC	secreted protein acidic and rich in cysteine
TN	tenascin
SIBLING	Small Integrin-Binding Ligand N-Linked Glycoprotein
Gla	γ-carboxyglutamate
MMP	matrix metalloprotease
Tsk1/+	tight skin 1
MRSS	modified Rodnan skin score
HADC	histone deacetylase
EC	endothelial cell
WT	wild-type
TLR	toll-like receptor
OPN	osteopontin
POSTN	periostin
MGP	matrix Gla protein