ABC	ATP-binding cassette
ABCB1	ATP-binding cassette, subfamily B (MDR/TAP), member 1
ABCC2	ATP-binding cassette, subfamily C (CFTR/MRP), member 2
ABCC3	ATP-binding cassette, subfamily C (CFTR/MRP), member 3
ABCC5	ATP-binding cassette, subfamily C (CFTR/MRP), member 5
ACT	anthracycline-induced cardiotoxicity
ACYP2	acylphosphatase 2
ADME	absorption, distribution, metabolism, excretion
AKT	AKT serine/threonine kinase
ALT	alanine transaminase
ATM	ataxia telangiectasia mutated)
ATR	ataxia telangiectasia and Rad3 related
ATRX	ATRX chromatin remodeler
AURKB	Aurora kinase B
B-Raf	B-Raf proto-oncogene, serine/threonine kinase
BRCA1	breast related cancer antigen 1
BRCA 2	breast related cancer antigen 2
Cas9	CRISPR associated protein 9
CBRs	carbonyl reductases
CCNE1	cyclin E1
CDK4	cyclin-dependent kinase 4
CDK6	cyclin-dependent kinase 6
CDKN2A	cyclin dependent kinase inhibitor 2A
CHST12	carbohydrate sulfotransferase 12
CI	confidence interval
CN	copy number
COMT	catechol O-methyltransferase
COSMIC	catalogue of somatic mutations in cancer
COX8A	cytochrome C oxidase subunit 8A
CRISPR	clustered regularly interspaced palindromic repeats
CTLA-4	cytotoxic T-lymphocyte antigen 4
CYP	cytochrome P450
DHFR	dihydrofolate reductase
DMEs	drug metabolizing enzymes
ERCC 1	excision repair cross-complementation group 1
ERCC 2	excision repair cross-complementation group 2
ERCC 5	excision repair cross-complementation group 5
ERK	extracellular signal-regulated kinase
EZH1	enhancer of zeste 1 polycomb repressive complex 2 subunit
EZH2	enhancer of zeste 2 polycomb repressive complex 2 subunit
FGFR	fibroblast growth factor receptor
GATA1	GATA binding protein 1
GGH	gamma-glutamyl hydrolase
GRM4	glutamate metabotropic receptor 4
GST	glutathione S-transferase
GSTM1	glutathione S-transferase M1
GSTM3	glutathione S-transferase M3
GSTP1	glutathione S-transferase P1
GSTT1	glutathione S-transferase T1
GWAS	genome-wide association study
HAS3	hyaluron synthase 3
HGOS	high-grade osteosarcoma
IL-8	interleukin-8
INFORM	INdividualized therapy FOr Relapsed Malignancies
lncRNAs	long non-coding RNAs
LP	likely pathogenic
LRP2	LDL receptor related protein 2, or megalin
MAPK	mitogen-activated protein kinase
MDM2	mouse double minute 2 (also known as murine double minute 2)
MDM4	mouse double minute 4
MEN1	menin 1
miRNAs	microRNAs
MMS19	nucleotide excision repair homolog
MSH2	mutS homolog 2
MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1
MTHFR	methylenetetrahydrofolate reductase
mTOR	mammalian target of rapamycin (mechanistic target of rapamycin)
MTX	methotrexate
NBN	nibrin
NER	nucleotide excision repair
NF1	neurofibromin 1
NFE	non-Finish European
NGS	next generation sequencing
NSG	NOD Scid gamma
odd ratio	OR
P	pathogenic
PARP1	poly (ADP-ribose) polymerase 1
PD-1	programmed cell death-1
PD-L1	programmed death-ligand 1
PDXs or PDTXs	patient-derived tumor xenografts
PI3K	phosphatidylinositol 3 kinase
PMS2	PMS1 homolog 2, mismatch repair system component
POT1	protection of telomeres 1
PRCKG	protein kinase CGMP-dependent 1
PTEN	phosphatase and tensin homolog
RAD21	RAD21 cohesin complex component
RARG	retinoic acid receptorγ
RB1	RB transcriptional corepressor 1 (also known as retinoblastoma gene 1)
RECQL2	RecQ like helicase 2
RECQL3	RecQ like helicase 3
RECQL4	RecQ like helicase 4
RECQL5	RecQ like helicase 5
RFC	reduced folate carrier
RPS19	ribosomal protein S19
RPS26	ribosomal protein S26
RUNX1	RUNX family transcription factor 1
SATB2	SATB homeobox 2
SCNAs	somatic copy number aberrations
SLC19A1	solute carrier family 19 (folate transporter) member 1 (also known as reduced folate carrier, RFC or reduced folate carrier 1, RFC1)
SLC22A17	solute carrier family 22 member 17
SLC22A2	solute carrier family 22 member 2
SLC22A7	solute carrier family 22 member 7
SLC22A8	solute carrier family 22 member 8
SLC28A3	solute carrier family 28 member 3
SLCO1B1	solute carrier organic anion transporter family member 1B1
SMARCA4	SWI/SNF related matrix associated actin dependent regulator of chromatin, subfamily A, member 4
SMARCB1	SWI/SNF related matrix associated actin dependent regulator of chromatin, subfamily B, member 1
SNPs	single nucleotide polymorphisms
SNV	somatic nucleotide variants
SV	structural variations
TARGET	Therapeutically Applicable Research to Generate Effective Treatments
TGFB1	transforming growth factor beta 1
TMB	tumor mutational burden
TNF	tumor necrosis factor
TP53	tumor protein 53
TPMT	thiopurine S-methyltransferase
TS	thymidylate synthase
TSC	TSC complex subunit
UGT1A6	UDP glucuronosyltransferase 1 A6
UGT2B15	UDP glucuronosyltransferase family 2 member B15
VEGF	vascular endothelial growth factor
VHL	Von Hippel-Lindau tumor suppressor
WES	whole-exome sequencing
WGS	whole-genome sequencing
XPC	xeroderma pigmentosum complementation group C
XRCC3	X-ray repair cross complementing 3