PD |
Parkinson’s Disease |
α-Syn |
α-synuclein |
ROT |
rotenone |
PQ |
paraquat |
MB |
maneb |
ROS |
reactive oxygen species |
H2O2
|
hydrogen peroxide |
GSH |
Glutathione |
BBB |
blood brain barrier |
CNS |
central nervous system |
ARs |
adenosine receptors |
MAO-B |
monoamine oxidase-B |
Nrf2 |
nuclear factor erythroid 2-related factor 2 |
PGC-1α |
peroxisome proliferator-activated receptor-gamma coactivator 1-α |
KO |
knockout |
PDE |
phosphodiesterase |
A2AR |
adenosine 2A receptor |
PKA |
protein kinase A |
TNF-α |
tumor necrosis factor alpha |
L-DOPA |
L-3,4-dihydroxyphenylalanine |
GABA |
γ-aminobutyric acid |
A1R |
adenosine 1 receptor |
MPTP |
N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine |
6-OHDA |
6-hydroxydopamine |
qRT-PCR |
quantitative real-time polymerase chain reaction |
DOPAC |
3,4 dihydroxyphenylacetic acid |
CSC |
8-(-3-chlorostyryl)-caffeine |
AIMs |
abnormal involuntary movements |
THP |
trihexyphenidyl |
ESS |
Epworth Sleepiness Scale |
UPDRS |
unified Parkinson’s Disease rating scale |
HC |
healthy control |
HPFS |
Study of Health Professionals |
NHS |
Nurses’ Health Study |