Table 2.

Description of clinical studies and mutations in exons of FGB and FGG genes encoding beta and gamma nodules of fibrinogen molecule associated with thrombotic complications.

Name/Origin	Plasma Protein	Native Protein	Gene	Gene Status	Type	Haemorraghes	Numbers of Studied Family Member/Positive Numbers of Mutation	Numbers of Thrombotic Complications	Other Thrombophilic States	References
Fibrinogen Bβ Chain Mutations Associated with Thrombosis
PARIS IX	Bβ(236) Tyr>Cys	p.Tyr266Cys	5909A>G IVS7+1G>C	Compound	Hypofib.	Yes	2/1	2	Not listed	[6]
ALGERIAN	Bβ(269) Tyr>His	p.Tyr299His	c.895T>C	Homozyg.	Afib.	Yes	1/1	1	Heterozygous Factor V Leiden mutation	[48]
NORTHERN ITALY	Bβ(277) Ala>Ser	p.Ala307Ser	c.919G>T	Homozyg.	Afib.	No	3/1	3	No other thrombophilic state	[67]
MARTIN II	Bβ(338) Tyr>His	p.Tyr368His	c.1102T>C	Homozyg.	Hypofib.	No	4/2	5	No other thrombophilic state	[26]
GENEVA	Bβ(17) Arg>Stop Bβ(414) Gly>Ser	p.Arg47Stop p.Gly444Ser	c.139C>T c.1330G>C	Compound	Afib.	Yes	4/2	2	No other thrombophilic state	[68]
MUMBAI	Bβ(434) Gly>Asp	p.Gly464Asp	c.G1391A	Homozyg.	Afib.	Yes	1/1	1	Heterozygous PAI 4G/5G polymorphism	[69]
PORTUGUESE	Bβ(442) Gly>Val	p.Gly472Val	c.1415G>T	Homozyg.	Hypofib.	No	1/1	5	No other thrombophilic state	[48]
Fibrinogen γ Chain Mutations Associated with Thrombosis
COLUMBUS	γ(200) Gly>Val	p.Gly226Val	c.677G>T	Heterozyg.	Hypofib.	Yes	8/2	2	Heterozygous Factor V Leiden, MTHFR C677T mutations	[70]
MARTIN III	γ(249) Glu>Stop	p.Glu275Stop	c.823G>T	Heterozyg.	Hypofib.	No	1/1	3	No other thrombophilic state	[5]
DARLINGHURST	γ(253) Trp>Gly	p.Trp279Gly	c.835T>G	Homozyg.	Hypofib.	Yes	2/1	2	No other thrombophilic state	[71]
SAINT GERMAIN II	γ(345) Asn>Ser	p.Asn371Ser	7687A>G	Heterozyg.	Hypofib.	No	3/1	2	Heterozygous Factor V Leiden mutation, prothrombin G20210 mutation	[72]

Afib, afibrinogenemia; Heterozyg, heterozygous; Heterozyg, heterozygous; Hypofibt, hypofibrinogenemia; PAI, plasminogen activator inhibitor-1.