3DCRT	three-dimensional conformation radiation therapy
5-FU	5-fluorouracil
ABCG2	ATP-binding cassette super-family G member 2
AKT	protein kinase B
Arg	arginase
ATM	ataxia telangiectasia mutated
ATP	adenosine triphosphate
BED	biological equivalent dose
BRCA2	breast cancer type 2 susceptibility protein
BR-PDAC	borderline resectable PDAC
CAF	cancer associated fibroblast
CCL2	chemokine ligand 2
CCR2	C-C chemokine receptor type 2
CDK4/6	cyclin-dependent kinase 4 and 6
CDKN2A	cyclin-dependent kinase inhibitor 2A
cGAS	cyclic GMP-AMP synthase
CRT	chemoradiotherapy
CSC	cancer stem cell
CSF1	colony-stimulating factor
CSF1R	colony-stimulating factor 1 receptor
CT	chemotherapy
CTLA4	cytotoxic T-lymphocyte associated protein 4
CXCR4	C-X-C motif chemokine receptor 4
DAMPs	damage associated molecular patterns
DC	denditric cell
EGFR	epidermal growth factor receptor
EMT	epithelial to mesenchymal transition
EORTC	European organisation for research and treatment of cancer
ERK	mitogen-activated protein kinase 1
ESPAC	European study group for pancreatic cancer
EV	extracellular vesicle
FLASH RT	ultrahigh dose-rate radiation therapy
GIST	gastrointestinal study group
HIF-1α	hypoxia inducible factor 1
HMGB-1	high mobility group box 1
HR	homologous recombination
ICD	immunogenic cell death
IFN-γ	interferon-γ
IMRT	intensity modulated radiation therapy
iNOS	inducible nitric oxide synthase
KRAS	kirsten rat sarcoma
LA-PDAC	locally advanced PDAC
LET	linear energy transfer
LPS	lipopolysaccharide
MDSC	myeloid-derived suppressor cells
MEK	mitogen-activated protein kinase kinase
MHC 1	major histocompatibility complex class 1
mTOR	mammalian target of rapamycin
nab-paclitaxel	nanoparticle-bound paclitaxel
NF-κB	nuclear factor kappa B
NHEJ	non homologous end joining
NRF2	nuclear factor erythroid 2-related factor 2
OAR	organ at risk
OS	overall survival
PARP	poly(ADP-ribose) polymerase
PDAC	pancreatic ductal adenocarcinoma
PD1	programmed cell death 1
PDK1	pyruvate dehydrogenase kinase 1
PD-L1	programmed cell death ligand 1
PDX	patient-derived xenograft
PI3K	phosphatidylinositol 3-kinase
POLO	pancreas cancer olaparib ongoing
PREOPANC	preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer
PRODIGE	trial comparing adjuvant chemotherapy with gemcitabine versus mfolfirinox to treat resected pancreatic adenocarcinoma
PT	proton therapy
RAF	rapidly accelerated fibrosarcoma
RAS	rat sarcoma
RBE	relative biological effectiveness
ROS	reactive oxygen species
R-PDAC	resectable PDAC
RT	radiotherapy
RTOG	radiation therapy oncology group
SBRT	stereotactic body radiation therapy
SDF-1	stromal derived factor 1
SMAD4	mothers against decapentaplegic homolog 4
SMART	stereotactic magnetic resonance guide adaption radiation therapy
SPArc	continuous spot-scanning protons arc
STING	stimulator of interferon genes
TAM	tumour-associated macrophages
TGFβ	transforming growth factor beta
TIL	tumour infiltrating lymphocytes
TNF	tumour necrosis factor
TRAIL	TNF-related apoptosis-inducing ligand
Trex1	three prime repair exonuclease 1
UPR	unfolded protein response
VEGF	vascular endothelial growth factor
Wnt	wingless-integration-1
ZEB	zinc finger E-box binding homeobox