Figure 1.

Schematic representation of the initial exon(s) of Lewy body disorders (LBD)-causing and the four main LBD-risk modifying genes with CpG islands. Names of the genes are indicated at the left. In red are autosomal dominant disease-causing genes, in black are autosomal recessive disease-causing genes, in blue are main risk factors, identified by genome-wide association studies (GWAS). Boxes represent exons: light blue—noncoding sequence; dark blue—coding sequence. Horizontal arrows indicate transcription start and direction; vertical arrows indicate the CDS start. Dots indicate CpG islands studied for methylation changes, in red is change of methylation levels, in blue is unchanged methylation. Light green box, miRNA gene within the SNCB sequence. Dark green box, lncRNA within the MAPT sequence.