Table 2.
Selected pathways deregulated after nCD NPs exposure.
| ID | Source | Deregulated Pathway | q-Value | Deregulated Genes (N) | Genes in Pathway (N) |
|---|---|---|---|---|---|
| nCD 4 h 100 µg/mL | |||||
| 83105 | KEGG | Pathways in cancer | <0.001 | 82 | 395 |
| 1268690 | REACTOME | Eukaryotic Translation Elongation | <0.001 | 49 | 98 |
| 1268679 | REACTOME | Eukaryotic Translation Initiation | <0.001 | 55 | 127 |
| 1268692 | REACTOME | Eukaryotic Translation Termination | <0.001 | 47 | 97 |
| 1269649 | REACTOME | Gene Expression | <0.001 | 345 | 1844 |
| 1268678 | REACTOME | Translation | <0.001 | 68 | 165 |
| nCD 24 h 10 µg/mL | |||||
| 83039 | KEGG | DNA Replication | <0.001 | 8 | 36 |
| 83055 | KEGG | p53 signaling pathway | <0.001 | 9 | 69 |
| 1269741 | REACTOME | Cell Cycle | <0.001 | 63 | 624 |
| 1269810 | REACTOME | M Phase | <0.001 | 26 | 311 |
| 1269768 | REACTOME | G1/S Transition | <0.001 | 18 | 121 |
| 1269772 | REACTOME | G1/S-Specific Transcription | <0.001 | 5 | 18 |
| 1269784 | REACTOME | DNA strand elongation | <0.001 | 11 | 32 |
| 1269742 | REACTOME | Cell Cycle Checkpoints | <0.001 | 16 | 204 |
| 1269777 | REACTOME | S Phase | <0.001 | 21 | 132 |
| nCD 24 h 100 µg/mL | |||||
| 83039 | KEGG | DNA Replication | <0.001 | 24 | 36 |
| 1269741 | REACTOME | Cell Cycle | <0.001 | 216 | 624 |
| 1269810 | REACTOME | M Phase | <0.001 | 104 | 311 |
| 1269768 | REACTOME | G1/S Transition | <0.001 | 49 | 121 |
| 1269772 | REACTOME | G1/S-Specific Transcription | <0.001 | 15 | 18 |
| 1269784 | REACTOME | DNA strand elongation | <0.001 | 25 | 32 |
| 1269742 | REACTOME | Cell Cycle Checkpoints | <0.001 | 66 | 204 |
| 1269777 | REACTOME | S Phase | <0.001 | 52 | 132 |
| 1268690 | REACTOME | Eukaryotic Translation Elongation | <0.001 | 38 | 98 |
| 1268679 | REACTOME | Eukaryotic Translation Initiation | <0.001 | 43 | 127 |
| 1268692 | REACTOME | Eukaryotic Translation Termination | <0.001 | 36 | 97 |
| 1270350 | REACTOME | DNA Repair | <0.001 | 80 | 319 |