Table 4.

Selected pathways based on miRNA-mRNA interactions deregulated after nCD NPs exposure.

ID	Deregulated Pathway	q-Value	miRNA (N)	Genes (N)
nCD 4 h 10 µg/mL
hsa00512	Mucin type O-Glycan biosynthesis	0.009	9	7
hsa04512	ECM-receptor interaction	<0.001	10	17
nCD 4 h 100 µg/mL
hsa00512	Mucin type O-Glycan biosynthesis	<0.001	46	23
hsa05214	Glioma	<0.001	78	52
hsa05210	Colorectal cancer	0.013	73	50
hsa05212	Pancreatic cancer	0.003	79	53
hsa05213	Endometrial cancer	0.022	72	42
hsa04310	Wnt signaling pathway	0.003	89	108
hsa04012	ErbB signaling pathway	<0.001	86	73
hsa05200	Pathways in cancer	<0.001	94	303
hsa04014	Ras signaling pathway	<0.001	91	175
hsa04010	MAPK signaling pathway	0.018	93	184
hsa04512	ECM-receptor interaction	<0.001	21	27
hsa00061	Fatty acid biosynthesis	<0.001	34	10
nCD 24 h 10 µg/mL
hsa00512	Mucin type O-Glycan biosynthesis	<0.001	26	20
hsa05214	Glioma	<0.001	46	49
hsa05210	Colorectal cancer	0.001	40	46
hsa05212	Pancreatic cancer	<0.001	45	50
hsa05213	Endometrial cancer	0.006	40	40
hsa04310	Wnt signaling pathway	0.007	52	93
hsa04012	ErbB signaling pathway	<0.001	51	66
hsa05200	Pathways in cancer	<0.001	59	260
hsa04014	Ras signaling pathway	0.002	55	145
hsa04010	MAPK signaling pathway	0.004	53	164
hsa04512	ECM-receptor interaction	<0.001	49	55
nCD 24 h 100 µg/mL
hsa00512	Mucin type O-Glycan biosynthesis	<0.001	51	23
hsa05214	Glioma	<0.001	69	55
hsa05210	Colorectal cancer	<0.001	71	57
hsa05212	Pancreatic cancer	<0.001	72	58
hsa05213	Endometrial cancer	<0.001	68	45
hsa04310	Wnt signaling pathway	<0.001	84	108
hsa04012	ErbB signaling pathway	<0.001	80	80
hsa05200	Pathways in cancer	<0.001	91	288
hsa04014	Ras signaling pathway	<0.001	87	171
hsa04010	MAPK signaling pathway	0.002	87	191
hsa04512	ECM-receptor interaction	0.002	72	61
hsa00061	Fatty acid biosynthesis	<0.001	34	9
hsa04660	T cell receptor signaling pathway	<0.001	72	85
hsa04666	Fc gamma R-mediated phagocytosis	0.024	77	66
hsa04210	Apoptosis	0.036	70	66
hsa04668	TNF signaling pathway	0.016	76	84