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Effects of PD98059, an ERK inhibitor, on tyrosinase activity in B16F10 cells. Cells were treated with α-MSH (200 nM) or PD98059 (10 μM) alone or in combination with or without PH at a single concentration of 12.5 µM. Results are expressed as percentages of the untreated cells. All experiments were carried out in triplicate, and the results are expressed as the mean ± SD. ** p < 0.01, aa p < 0.01, bb p < 0.01.
