Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 30;21(13):4646. doi: 10.3390/ijms21134646

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effects of NRF2 knockdown on 5-FUR pancreatic cancer cells (CPFAC-1 and BxPC-3). (a) DCFDA staining revealed that ROS levels were higher in siNRF2 5-FUR PDAC cells than in the siNC 5-FUR PDAC cells; (b) expression of NRF2 (n = 5), HO-1 (n = 3), NQO-1 (n = 3), and ABCG-2 (n = 3) was downregulated in siNRF2 5-FUR PDAC cells, as determined by RT-qPCR; (c) Western blotting confirmed that levels of ABCG-2, HO-1, and N-cadherin were decreased, while those of E-cadherin were increased in siNRF2 5-FUR PDAC cells; (d) MTT assay results revealed that the antitumor effect of 5-FU was significantly more potent in siNRF2 5-FUR PDAC cells than in the negative control (NC) cells. * p < 0.05.