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. 2020 Jun 29;21(13):4631. doi: 10.3390/ijms21134631

Figure 3.

Figure 3

Effects of 4′-F-PCP on self-administration under fixed ratio (FR) schedule in rats. (A) Experimental timeline for 4′-F-PCP self-administration under FR and progressive ratio (PR) schedules of reinforcement. (B–D) Temporal analysis of mean number of infusions, active lever presses, and inactive lever presses during a 2 h session under FR1 and FR2 schedules. (E,F) Mean of total number of infusions for a 2 h session under FR1 and FR2 schedules. Asterisks *, **, and *** indicate p < 0.05, p < 0.01, and p < 0.001, respectively, vs. saline self-administered group. (G,H) Mean of intake amount of 4′-F-PCP for a 2 h session under FR1 and FR2. Asterisks *** indicate p < 0.001 vs. 0.1 and 0.3 mg/kg/infusion 4′-F-PCP group. (I) Representative hatchmarks indicate the infusion patterns of saline and 4′-F-PCP at the final self-administration session of FR2 schedules. SAL: saline. n = 6 per group.