Figure 3.

(a) Schematic drawing of histological section of the wound model for evaluation of wound healing. Epithelial gap (EG) and total area of granulation tissue were analyzed using digital image analysis software. E = epithelium, G = granulation tissue, D = dermis, F = fat. Epithelial gap was analyzed using digital image analysis software. Granulation tissue area was measured by tracing regions of granulation tissue and calculating pixel area. The sum of the regions was defined as the GT area. (b) Histological section of wound in db/db mice. E = epithelium, G = granulation tissue, D = dermis, F = fat. (c) Histological comparison of epithelial gap and granulation tissue formation in PBS-treated and PBS + mOMSCs-treated db/db mice and WT control. (d) Comparison of epithelial gap in PBS + mOMSCs-treated and PBS-treated db/db mice. EG was assessed at days 0, 7 and 11 after wounding, H&E staining. (e) Effect of treatment on the rate of GT formation in db/db mice as assessed at days 0, 7 and 11 after wounding