Table 1.
Secretome of irradiated PBMCs suppresses inflammation in Nrf2 knockout macrophages.
| LPS | LPS+Secretome | SLV | SLV+Secretome | |
|---|---|---|---|---|
| Nrf2 KO (1) | 149.6 | 93.5 | 539.4 | 182.9 |
| Nrf2 KO (2) | 273.8 | 251.9 | 297.5 | 234.2 |
| WT (1) | 458.0 | 88.6 | 510.4 | 76.1 |
| WT (2) | 342.o | 92.1 | 404.0 | 118.2 |
Murine bone marrow-derived macrophages from Nrf2 knockout mice and the respective controls (WT) were exposed to the secretome corresponding to 1 × 107 irradiated PBMCs/mL. The inflammation was provoked by 100 ng/mL LPS or 5% saliva (SLV). The data show the x-fold increase of IL1 expression compared to unstimulated control. Data show two independent experiments (1, 2).