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Three major subfamilies of mitogen-activated protein kinases (MAPKs) include extracellular signal-regulated kinases (ERKs), the c-Jun amino-terminal kinases (JNKs), and the p38 MAPKs. The solid lines ending with arrowheads denote activated proteins, solid lines with blunt ends denote deactivated proteins, and the dotted lines with blunt ends denote partially deactivated proteins.
