Figure 2.

Change in endogenous neurosteroid levels. (A) In the AD brain. A general trend of lower levels of neuroactive steroids was observed in different brain regions of AD patients than nondemented controls (*significant decrease in steroid levels). Participants were women and men with mean age 86 ± 2 years [39], 77.3 ± 2 years [42] or only men with median age 83.0 years [41]. (B) Under in vitro and in vivo Aβ burden conditions. ↓: decrease, ↑: increase, ↔: no change vs. Aβ.