AD	Alzheimer’s disease
ApoE	apolipoprotein
APP	amyloid precursor protein
Aβ	Amyloid-β
CNS	central nervous system
CSF	cerebrospinal fluid
DHEA	dehydroepiandrosterone
DHEAS	dehydroepiandrosterone sulfate
E2	17β-estradiol
FTD	frontotemporal dementia
GABAA-R	γ-aminobutyric acid type A receptor
GC-MS	gas chromatography-mass spectrometry
IL-1β	interleukin-1β
mTOR	mechanistic target of rapamycin
NF-κB	nuclear factor-kappa B
NTFs	neurofibrillary tangles
P450scc	P450side chain cleavage
PI3K	phosphoinositide 3-kinase
PREG	pregnenolone
PREGS	pregnenolone sulfate
PROG	progesterone
PS1	presenilin-1
ROS	reactive oxygen species
TNFα	tumor necrosis factor alpha
TSPO	18 kDa translocator protein
yrs.	years
3 xTg-AD	triple transgenic mouse bearing the human APPSWE, TauP301L, and PS1M146V genes linked to AD and FTD
3α,5α-THP	3α,5α-tetrahydroprogesterone, allopregnanolone
3α-HSD	3α-hydrosteroid dehydrogenase
3β-HSD	3α-hydroxysteroid dehydrogenase-D5Δ5→Δ4D4 isomerase
3β-HST	3β-hydroxysteroid sulfotransferase
5α-DHP	5α-dihydroprogesterone
17β-HSD	17α-hydroxysteroid dehydrogenase