TBI	Traumatic brain injury;
EBI	Early brain injury;
SAH	Subarachnoid hemorrhage;
HMGB1	High mobility group box 1;
RAGE	Receptor for advanced glycation end products;
TLRs	Toll-like receptors;
DAMP	Damage-associated molecular patterns;
JAK	Janus kinases;
STAT3	Signal transducer and activator of transcription 3;
MD-2	Myeloid differentiation factor-2;
BBB	Blood–brain barrier;
CNS	Central nervous system;
GFAP	Glial fibrillary acidic protein;
IL	Interleukin;
IBA1	Ionized calcium-binding adapter molecule 1;
iNOS	Inducible nitric oxide synthase;
NADPH	Nicotinamide-adenine dinucleotide phosphate;
NF-κB	Nuclear factor κ light chain enhancer of activated B cells;
TNF-α	Tumor necrosis factor-α;
IR	Immunoreactivity;
FPI	Fluid percussion injury;
Anti-HMGB1 mAb	Anti-HMGB1 monoclonal antibody;
SD	Sprague-Dawley;
IFN-γ	Interferon-gamma;
VEGF	Vascular endothelial growth factor;
CCI	Controlled cortical impact;
ICP	Intracranial pressure;
ICH	Intracerebral hemorrhage;
DAI	Diffuse axonal injury;
WT	Wild-type;
MMP	Matrix metalloproteinase;
MAPK	Mitogen-activated protein kinase
MAP2	Microtubule-associated protein 2;
AQP4	Aquaporin-4;
VSMC	Vascular smooth muscle cells;
ICAM	Intercellular adhesion molecule;
VCAM	Vascular cell-adhesion molecule;
PI3K/AKT	Phosphoinositide 3-kinases/protein kinase B;
GCS	Glasgow Coma Scale