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. 2020 Jul 5;21(13):4774. doi: 10.3390/ijms21134774

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Therapeutic effects of ASC-exosomes on cisplatin-induced AKI in rats. (A) Number of surviving animals over time. (B) Changes in relative body weight over time. The levels of (C) blood urea nitrogen (BUN) and (D) serum creatinine over time. Results are presented as mean ± SEM. n = 10 for each group. *p < 0.05, **p < 0.01 and ***p < 0.001 vs cisplatin control group. Vehicle: normal rat injected with vehicle control; cisplatin: cisplatin-challenged rat injected with vehicle control; other: cisplatin-challenged rat injected with indicated dose per head of ASC-exosomes; x2: two times administration of ASC-exosomes on day 0 and 2.