Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 30;21(13):4676. doi: 10.3390/ijms21134676

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Characterization of the ACF animal model: ACF impacts right heart hypertrophy and collagen accumulation, leading to PA fibrosis. (a) A schematic description of the creation of ACF in rats, an experimental model of volume-overload CHF. (b) Oxygenation index of the IVC in the sham, ACF and MCT-PAH groups. (c) The ratio of RV to LV plus septum weight (RV/LV+S) is shown. Means ± SEMs, *** p < 0.001 versus sham. (d) Representative Masson’s trichrome collagen staining in the PAs from the sham, ACF and MCT-PAH rat models. The PA tissue from an ACF model had significantly increased collagen accumulation in the adventitial layers compared with that in the sham and MCT-PAH models.