. 2020 Jun 29;21(13):4618. doi: 10.3390/ijms21134618

Table 2.

Summary table.

Biological Activity	Molecular Target	Name/Number	Ref.	Origin
Antioxidant	Free radicals	3	[30]	Synthetic
Antioxidant	Free radicals	9	[35]	Synthetic
Antioxidant	Free radicals	10d	[36]	Synthetic
Antioxidant	Free radicals	15	[38]	Synthetic
Antiprolifera-tive	DNA, chromatin	18	[45]	Natural
Antiprolifera-tive	Topoisomerase 1	20	[47]	Synthetic
Antiprolifera-tive	Tumor-suppressor protein p53	21	[49]	Synthetic
Anticancer		22a-l	[50]	Synthetic
Anticancer	STAT3	23	[55]	Synthetic
Anticancer	Carbonic Anhydrase IX and XII	24	[70]	Natural
Anticancer	Carbonic Anhydrase IX and XII	26–37	[71]	Synthetic
Antibacterial/antifungal	S. aureus, E. coli, P. aeruginosa, A. niger, A. flavus, C. albicans	38,39	[79]	Synthetic
Antibacterial	S. aureusus, E.faecalis, E. coli	40,41a–e	[80]	Synthetic
Antibacterial	S. aureus DNA gyrase	42–49	[82]	Synthetic
Antibacterial	S. aureus	50,51	[83]	Synthetic
Modulator of antibiotics	n.g.	isopimpinellin imperatorin	[85]	Natural
Antibacterial	S. aureus, S. epidermidis, P. aeruginosa, E. cloacae, K. Pneumoniae, E. coli	6′,7′-dihydroxybergamottin, peucedanin, officinali isobutyrate	[86]	Natural
Antibacterial	S. aureus, L. monocytogenes, E. coli, Salmonella—inhibitors of Topo II and Topo IV	52–54	[87]	Synthetic
Antifungal	C. albicans -P450 cytochrome lanosterol 14α-demethylase	55–59	[94]	Synthetic
Antifungal	C. albicans—inhibition ergosterol biosynthesis by binding lanosterol 14a-demethylase	60,61	[95]	Synthetic
Antifungal	Several Candida strains—mode of action involving CYP51 and additional unidentified mechanism	62	[96]	Synthetic
Antifungal	C. albicans	marmesin senesioate, suberosin, crenulatin	[97]	Natural
Antifungal	C. albicans—antibiofilm action	coumarin	[100]	Natural
Antifungal	F. oxysporum, A. flavus, A. niger	63–68	[102]	Synthetic
Antiviral	Anti-HIV reverse transcriptase	69–71	[113]	Natural
Antiviral	HIV reverse transcriptase	72–74	[116]	Natural
Antiviral	HIV1-IN	75–78	[117]	Synthetic
Antiviral	H1N1 virus	79–82	[125]	Synthetic
Antiviral	Influenza A virus	83	[128]	Synthetic
Antiviral	Influenza A/PR8/H1N1 viruses—probably could affect intracellular redox-sensitive pathways	84–89	[129]	Synthetic
Antiviral	Hepatitis C virus	90–92	[130]	Synthetic
Antiviral	Hepatitis B virus	esculetin	[131]	Natural
Antiinflamma-tory	COX2	93–100	[143]	Synthetic
Antiinflamma-tory	5-LOX	101,102	[146]	Synthetic
Antiinflamma-tory	NO production	103	[147]	Natural
Antiinflamma-tory	NF-kB and p38/MAPK signaling pathways	osthole	[150]	Natural
Antiinflamma-tory	NF-kB signaling pathways	104	[151]	Synthetic
Anti-Alzhemer’s disease	AChE, BuChE, BACE1	105	[162]	Synthetic
Anti-Alzhemer’s disease	AChE, BuChE, BACE1, metal chelation	107	[163]	Synthetic
Anti-Alzhemer’s disease	AChE, BuChE, BACE1	108	[163]	Synthetic
Anti-Alzhemer’s disease	AChE, BuChE	111a	[166]	Synthetic
Anti-Alzhemer’s disease	AChE, BuChE, MAO-B	117	[167]	Synthetic
Anti-Alzhemer’s disease	AChE, BuChE, MAO-B, β-amyloid aggregation	136	[169]	Synthetic
Anticonvulsant	GABAergic system	148	[180]	Synthetic
Anticonvulsant	BDZ receptor	152d	[183]	Synthetic
Anticoagulant	VKOR inhibitor	Tecarfarin(ATI-5923)	[195,196,197,198]	Synthetic
Anticoagulant	n.g.	154,155	[199]	Synthetic
Anticoagulant	murine VKORC1 inhibitor	156	[200]	Synthetic
Anticoagulant	n.g.	157	[203]	Natural
Antidiabetic	α-glucosidases	158d,e	[207]	Synthetic
Antidiabetic	α-glucosidases	159d,e	[207]	Synthetic
Antidiabetic	α-glucosidases	165	[214]	Synthetic
Antidiabetic	α-glucosidases	168c	[215]	Synthetic
Antidiabetic	Insulin release	169–171	[217]	Synthetic
Photocleavable protecting groups	-	172–174	[231,232]	Synthetic
Photocleavable protecting group	-	175	[224]	Synthetic
Photocleavable protecting groups	-	176–178	[233]	Synthetic
Ionic probe	GHS (in the presence of Cu²⁺) and ClO⁻	179	[236,237]	Syntehtic
Ionic probe	ClO⁻	180	[238]	Synthetic
Ionic probe	ClO⁻, Cu²⁺	181	[239]	Synthetic
Ionic probe	ClO⁻	182–184	[240]	Synthetic
Ionic probe	Cu²⁺	185	[241]	Synthetic
Ionic probe	Cu²⁺	186	[242]	Synthetic
Ionic probe	Cu²⁺	187	[243]	Synthetic
Ionic probe	Cu²⁺, Al³⁺, Arg, Lys, Cys, Hcy, GSH	188	[244]	Synthetic
Ionic probe	Pd²⁺	189	[245]	Synthetic
Ionic probe	Hg²⁺	190,191	[246]	Synthetic
Ionic probe	Fe³⁺	192	[247]	Synthetic
Ionic probe	F⁻	193	[248]	Synthetic
Ionic probe	F⁻, Ca²⁺	194	[249]	Synthetic
Ionic probe	F⁻, CN⁻	195	[250]	Synthetic
Probe	HSO₃⁻, SO₃²⁻ ion	196	[251]	Synthetic
Probe	HSO₄⁻ and SO₄²⁻	CG, CA	[256]	Synthetic
Antibacterial	R. Solanacearum, genes fliA, flhC, biofilm formation	umbelliferone, esculetin, daphnetin, xanthotol	[261]	Natural
Fungicide	Colletotrichum sp.	197–202	[265]	Natural
Fungicide	Botrytis cinerea, Alternaria solani, Gibberella zeae, Rhizoctorzia solani, Cucumber anthrax and Alternaria	203,204	[268]	Synthetic
Fungicide:	Alternaria solani sorauer, Fusarium oxysporum f.sp. vasinfectum and Fusarium moniliforme	205a–d	[273]	Synthetic
Anticancer	MCF-7 human breast cancer cells	207–213	[276]	Synthetic
Anticancer	Human lung adenocarcinoma (A549/DDP) and HeLa cells	214–224	[281]	Synthetic
Catalyst		225	[282]	Synthetic