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. 2020 Feb 10;27(8):2330–2343. doi: 10.1038/s41418-020-0505-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The tumor progression of masses in PDX mice that received LY3039478 was delayed compared with vehicle and gemcitabine. Extra 18 days for LY3039478 group and extra 11 days for gemcitabine group after treatment end were given. The results show a slow recovery of progression in both treatment groups compared with the control group (vehicle) (b). At the end of the experiments, the size and weight (a) of the masses were visibly smaller than the control masses. **P < 0.01, ***P < 0.001 compared with treatment with vehicle.